|Application ||WB, E|
|Calculated MW||83201 Da|
|Antigen Region||199-228 aa|
|Other Names||Transducin-like enhancer protein 1, E(Sp1) homolog, Enhancer of split groucho-like protein 1, ESG1, TLE1|
|Target/Specificity||This TLE1 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 199-228 amino acids from the Central region of human TLE1.|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TLE1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.|
|Cellular Location||Nucleus. Note=Nuclear and chromatin-associated, depending on isoforms and phosphorylation status. Hyperphosphorylation decreases the affinity for nuclear components|
|Tissue Location||In all tissues examined, mostly in brain, liver and muscle|
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Provided below are standard protocols that you may find useful for product applications.
Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Carvalho, L.R., et al. Mol. Endocrinol. 24(4):754-765(2010)
Ali, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 107(9):4165-4169(2010)
Jagdis, A., et al. Am. J. Surg. Pathol. 33(12):1743-1751(2009)
Buscarlet, M., et al. PLoS ONE 4 (12), E8107 (2009) :
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