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LYPD6B Antibody (Center) (Ascites)
Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q8NI32 |
| Other Accession | Q9D7F2, NP_808879.2 |
| Reactivity | Human, Mouse |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2b |
| Clone/Animal Names | 634CT7.10.1 |
| Calculated MW | 20656 Da |
| Antigen Region | 79-108 aa |
| Gene ID | 130576 |
|---|---|
| Other Names | Ly6/PLAUR domain-containing protein 6B, LYPD6B |
| Target/Specificity | This LYPD6B antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 79-108 amino acids from the Central region of human LYPD6B. |
| Dilution | WB~~1:500~4000 E~~Use at an assay dependent concentration. |
| Format | Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | LYPD6B Antibody (Center) (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LYPD6B |
|---|---|
| Function | Likely acts as a modulator of nicotinic acetylcholine receptors (nAChRs) activity (PubMed:26586467, PubMed:34631692). In vitro acts on nAChRs in a subtype- and stoichiometry-dependent manner (PubMed:26586467). Modulates specifically alpha-3(3):beta-4(2) nAChRs by enhancing the sensitivity to ACh, decreasing ACh-induced maximal current response and increasing the rate of desensitization to ACh; has no effect on alpha-7 homomeric nAChRs; modulates alpha-3(2):alpha- 5:beta-4(2) nAChRs in the context of CHRNA5/alpha-5 variant Asn-398 but not its wild-type sequence (PubMed:26586467). However, according to another report in vitro it can weakly inhibits alpha-7 nAChRs (PubMed:34631692). |
| Cellular Location | Cell membrane; Lipid-anchor, GPI- anchor |
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Provided below are standard protocols that you may find useful for product applications.
Background
The function of this protein is unknown.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Ni, J., et al. Mol. Biol. Rep. 36(4):697-703(2009)
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