|Application ||WB, E|
|Calculated MW||30037 Da|
|Antigen Region||37-65 aa|
|Other Names||Catechol O-methyltransferase, COMT|
|Target/Specificity||This COMT antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 37-65 amino acids from the N-terminal region of human COMT.|
|Format||Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||COMT Antibody (N-term) (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.|
|Cellular Location||Isoform Soluble: Cytoplasm.|
|Tissue Location||Brain, liver, placenta, lymphocytes and erythrocytes|
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Provided below are standard protocols that you may find useful for product applications.
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.
Paloyelis, Y., et al. Neuropsychopharmacology 35(12):2414-2426(2010)
Stroth, S., et al. Neurobiol Learn Mem 94(3):364-372(2010)
Lim, J.H., et al. Pharmacogenet. Genomics 20(10):605-610(2010)
Demetrovics, Z., et al. Compr Psychiatry 51(5):510-515(2010)
Bodenmann, S., et al. Sleep 33(8):1027-1035(2010)
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