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COMT Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P21964 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 30 24(R&D 25 and 30 kDa) |
| Antigen Region | 84-110 aa |
| Gene ID | 1312 |
|---|---|
| Other Names | Catechol O-methyltransferase, COMT |
| Dilution | WB~~1:1000 |
| Format | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.09% (W/V) sodium azide and 50% glycerol. |
| Storage Conditions | -20℃ |
| Name | COMT (HGNC:2228) |
|---|---|
| Function | Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. |
| Cellular Location | [Isoform Soluble]: Cytoplasm |
| Tissue Location | Brain, liver, placenta, lymphocytes and erythrocytes |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
References
Lundstroem K.,et al.DNA Cell Biol. 10:181-189(1991).
Bertocci B.,et al.Proc. Natl. Acad. Sci. U.S.A. 88:1416-1420(1991).
Tenhunen J.,et al.Eur. J. Biochem. 223:1049-1059(1994).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11(2004).
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