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GDF11 Antibody

Purified Mouse Monoclonal Antibody (Mab)

     
  • WB - GDF11 Antibody AM8665b
    Anti-GDF11 Antibody at 1:2000 dilution + GDF11 recombinant protein Lysates/proteins at 20 ng per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 28 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession O95390
Reactivity Human
Predicted Human
Host Mouse
Clonality monoclonal
Isotype IgG1,κ
Clone Names 1956CT308.38.25
Calculated MW 45091 Da
Additional Information
Gene ID 10220
Other Names Growth/differentiation factor 11, GDF-11, Bone morphogenetic protein 11, BMP-11, GDF11, BMP11
Target/Specificity This GDF11 antibody is generated from a mouse immunized with a recombinant protein from the human region of human GDF11.
Dilution WB~~1:2000
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGDF11 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GDF11
Synonyms BMP11 {ECO:0000303|PubMed:10075854}
Function Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. May play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern (By similarity). Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3 (PubMed:28257634).
Cellular Location Secreted.
Research Areas
Citations (0)

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Background

Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern.

References

Gamer L.W.,et al.Dev. Biol. 208:222-232(1999).
McPherron A.C.,et al.Nat. Genet. 22:260-264(1999).

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$ 162.50
$ 54.50
Cat# AM8665b
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