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Synaptojanin I Antibody

Purified mouse monoclonal antibody

  • IHC - Synaptojanin I Antibody AN1178
    Immunohistochemical analysis of paraffin-embedded R. brain section using Synaptojanin I Antibody (Cat#AN1178). AN1178 was diluted at 1:100 dilution. A peroxidase-conjugated goat anti-rabbit IgG at 1:400 dilution was used as the secondary antibody, followed by DAB staining.
  • WB - Synaptojanin I Antibody AN1178
    Western blot of rat hippocampal lysate showing specific immunolabeling of the ~145k synaptojanin I protein.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q62910
Reactivity Rat
Host Mouse
Clonality monoclonal
Isotype IgG1
Clone Names 5H1
Calculated MW 145 KDa
Additional Information
Gene ID 85238
Gene Name SYNJ1
Other Names Synaptojanin-1, Synaptic inositol 1, 5-trisphosphate 5-phosphatase 1, Synj1
Target/Specificity Recombinant protein from the C-terminal region of rat synaptojanin 1.
Dilution IHC~~1:100
WB~~ 1:1000
Format Protein G purified culture supernatant.
Antibody Specificity Specific for the ~145k synaptojanin I protein in Western blots of rat brain extracts. Immunolabeling blocked by preadsorption of antibody with the protein used to generate the antibody.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSynaptojanin I Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
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Research Areas
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Synaptojanin is a phosphatidylinositol phosphatase involved in clathrin-mediated endocytosis of synaptic vesicles. Synaptojanin 1 has two alternatively spliced isoforms; one that is ~ 145 kDA and is exclusively expressed in neurons, and the other ~ 170 kDa which is expressed in non-neuronal, peripheral tissues (Ramjaun AR & McPherson PS, 1996). The gene which encodes Synaptojanin 1, SYNJ1, has been mapped to chromosome 21 thus making it a candidate for involvement in Down’s syndrome (DS). It has recently been demonstrated that Ts65Dn mice (the most commonly used model of DS) have altered phosphatidylinositol-4,5-bisphosphate metabolism. This defect is rescued by restoring SYNJ1 to disomy in the Ts65Dn mice (Voronov SV et al., 2008).


Tissue-specific alternative splicing generates two synaptojanin isoforms with differential membrane binding properties (1996). Ramjaun AR, McPherson PS. J Biol Chem. Oct 4;271(40):24856-61.
Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome (2008) .Voronov SV, Frere SG, Giovedi S, Pollina EA, Borel C, Zhang H, Schmidt C, Akeson EC, Wenk MR, Cimasoni L, Arancio O, Davisson MT, Antonarakis SE, Gardiner K, De Camilli P, Di Paolo G. Proc Natl Acad Sci U S A. Jul 8;105(27):9415-20.

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$ 365.00
Cat# AN1178
Availability: 7-10 days
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