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Anti-Synaptojanin 1 Antibody
Our Anti-Synaptojanin 1 primary antibody from PhosphoSolutions is mouse monoclonal. It detects rat S
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q62910 |
| Reactivity | Bovine |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Clone Names | 5H1 |
| Calculated MW | 172881 Da |
| Gene ID | 85238 |
|---|---|
| Other Names | 4 antibody, 5-trisphosphate 5-phosphatase 1 antibody, Inositol 5' phosphatase (synaptojanin 1) antibody, Inositol 5' phosphatase antibody, INPP 5G antibody, INPP5G antibody, KIAA0910 antibody, PARK20 antibody, Polyphosphoinositide phosphatase antibody, Synaptic inositol 1 4 5 trisphosphate 5 phosphatase 1 antibody, Synaptic inositol 145 trisphosphate 5 phosphatase 1 antibody, Synaptic inositol-1 antibody, Synaptojanin antibody, Synaptojanin 1 antibody, Synaptojanin 1 polyphosphoinositide phosphatase antibody, Synaptojanin-1 antibody, Synaptojanin1 antibody, Synj 1 antibody, Synj1 antibody, SYNJ1_HUMAN antibody |
| Target/Specificity | Synaptojanin is a phosphatidylinositol phosphatase involved in clathrin-mediated endocytosis of synaptic vesicles. Synaptojanin 1 has two alternatively spliced isoforms; one that is ~ 145 kDA and is exclusively expressed in neurons, and the other ~ 170 kDa which is expressed in non-neuronal, peripheral tissues (Ramjaun AR & McPherson PS, 1996). The gene which encodes Synaptojanin 1, SYNJ1, has been mapped to chromosome 21 thus making it a candidate for involvement in Down’s syndrome (DS). It has recently been demonstrated that Ts65Dn mice (the most commonly used model of DS) have altered phosphatidylinositol-4,5- bisphosphate metabolism. This defect is rescued by restoring SYNJ1 to disomy in the Ts65Dn mice (Voronov SV et al., 2008). |
| Format | Protein G Purified |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Anti-Synaptojanin 1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Shipping | Blue Ice |
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Provided below are standard protocols that you may find useful for product applications.
Background
Synaptojanin is a phosphatidylinositol phosphatase involved in clathrin-mediated endocytosis of synaptic vesicles. Synaptojanin 1 has two alternatively spliced isoforms; one that is ~ 145 kDA and is exclusively expressed in neurons, and the other ~ 170 kDa which is expressed in non-neuronal, peripheral tissues (Ramjaun AR & McPherson PS, 1996). The gene which encodes Synaptojanin 1, SYNJ1, has been mapped to chromosome 21 thus making it a candidate for involvement in Down’s syndrome (DS). It has recently been demonstrated that Ts65Dn mice (the most commonly used model of DS) have altered phosphatidylinositol-4,5- bisphosphate metabolism. This defect is rescued by restoring SYNJ1 to disomy in the Ts65Dn mice (Voronov SV et al., 2008).
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