|Calculated MW||156333 Da|
|Target/Specificity||Synthetic phospho-peptide corresponding to amino acid residues surrounding Thr1160 conjugated to KLH|
|Format||Antigen Affinity Purified from Pooled Serum|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Insulin Receptor (Thr1160) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
The insulin receptor (IR) is a well-studied receptor tyrosine kinase composed of two α subunits, responsible for the extracellular insulin binding site, and two β subunits, responsible for intracellular protein kinase activity (Endemann et al., 1990, Chiu et al., 2010). The binding of insulin to the α subunits activates the intrinsic kinase activity located in the β subunits and subsequently initiates a cascade of phosphorylation events causing major conformational changes in the activation loop of the kinase domain, which lead to different biological functions (Chiu et al., 2010). It has been hypothesized that T1160 phosphorylation affects or is affected by Y1158/62/63 phosphorylation and that the conformation of T1160 and pT1160 is likely to be affected by the phosphorylation status of the surrounding tyrosines.
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