|Application ||WB, E|
|Other Accession||NP_612210.4, NP_963917.2|
|Calculated MW||30762 Da|
|Antigen Region||178-206 aa|
|Other Names||C-type lectin domain family 12 member A, C-type lectin-like molecule 1, CLL-1, Dendritic cell-associated lectin 2, DCAL-2, Myeloid inhibitory C-type lectin-like receptor, MICL, CLEC12A, CLL1, DCAL2, MICL|
|Target/Specificity||This CLEC12A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 178-206 amino acids from the Central region of human CLEC12A.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CLEC12A Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CLL1, DCAL2, MICL|
|Function||Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.|
|Cellular Location||Cell membrane; Single-pass type II membrane protein Note=Ligand binding leads to internalization|
|Tissue Location||Detected in normal myeloid cells and in acute myeloid leukemia cells. Detected in neutrophils, eosinophils, monocytes and dendritic cells. Detected in spleen macrophage-rich red pulp and in lymph node (at protein level). Detected in peripheral blood leukocytes, dendritic cells, bone marrow, monocytes, mononuclear leukocytes and macrophages|
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