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ATXN7L3B Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- BACKGROUND
Application 
| WB, FC, E |
|---|---|
| Primary Accession | Q96GX2 |
| Other Accession | NP_001129734.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 10771 Da |
| Antigen Region | 32-62 aa |
| Gene ID | 552889 |
|---|---|
| Other Names | Putative ataxin-7-like protein 3B, ATXN7L3B |
| Target/Specificity | This LOC552889 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 32-62 amino acids from the Central region of human LOC552889. |
| Dilution | WB~~1:1000 FC~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ATXN7L3B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ATXN7L3B |
|---|---|
| Function | By binding to ENY2, interferes with the nuclear functions of the deubiquitinase (DUB) module of the SAGA complex which consists of ENY2, ATXN7, ATXN7L3 and the histone deubiquitinating component USP22. Affects USP22 DUB activity toward histones indirectly by changing the subcellular distribution of ENY2 and altering ENY2 availability for ATXN7L3 interaction. Regulates H2B monoubiquitination (H2Bub1) levels through cytoplasmic sequestration of ENY2 resulting in loss of nuclear ENY2-ATXN7L3 association which destabilizes ATXN7L3. Affects protein expression levels of ENY2 and ATXN7L3. |
| Cellular Location | Cytoplasm. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 150.00
$ 385.00
Cat# AP10056c
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