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PP1R14C Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q8TAE6 |
| Other Accession | NP_112211.1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 17843 Da |
| Antigen Region | 126-155 aa |
| Gene ID | 81706 |
|---|---|
| Other Names | Protein phosphatase 1 regulatory subunit 14C, Kinase-enhanced PP1 inhibitor, PKC-potentiated PP1 inhibitory protein, Serologically defined breast cancer antigen NY-BR-81, PPP1R14C, KEPI |
| Target/Specificity | This PP1R14C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 126-155 amino acids from the C-terminal region of human PP1R14C. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PP1R14C Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PPP1R14C |
|---|---|
| Synonyms | KEPI |
| Function | Inhibitor of the PP1 regulatory subunit PPP1CA. |
| Cellular Location | Cytoplasm. Membrane; Peripheral membrane protein |
| Tissue Location | Detected in breast cancer. |
Provided below are standard protocols that you may find useful for product applications.
Background
The degree of protein phosphorylation is regulated by a balance of protein kinase and phosphatase activities. Protein phosphatase-1 (PP1; see MIM 176875) is a signal-transducing phosphatase that influences neuronal activity, protein synthesis, metabolism, muscle contraction, and cell division. PPP1R14C is an inhibitor of PP1 (Liu et al., 2002 [PubMed 11812771]).[supplied by OMIM].
References
Daskalow, K., et al. Anticancer Res. 30(5):1573-1578(2010)
Scholz, S.W., et al. Ann. Neurol. 65(5):610-614(2009)
Burgner, D., et al. PLoS Genet. 5 (1), E1000319 (2009) :
Mungall, A.J., et al. Nature 425(6960):805-811(2003)
Liu, Q.R., et al. J. Biol. Chem. 277(15):13312-13320(2002)
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