- CITATIONS: 1
|Application ||IHC-P, WB, E|
|Calculated MW||17843 Da|
|Antigen Region||126-155 aa|
|Other Names||Protein phosphatase 1 regulatory subunit 14C, Kinase-enhanced PP1 inhibitor, PKC-potentiated PP1 inhibitory protein, Serologically defined breast cancer antigen NY-BR-81, PPP1R14C, KEPI|
|Target/Specificity||This PP1R14C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 126-155 amino acids from the C-terminal region of human PP1R14C.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PP1R14C Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inhibitor of the PP1 regulatory subunit PPP1CA.|
|Cellular Location||Cytoplasm. Membrane; Peripheral membrane protein|
|Tissue Location||Detected in breast cancer.|
Provided below are standard protocols that you may find useful for product applications.
The degree of protein phosphorylation is regulated by a balance of protein kinase and phosphatase activities. Protein phosphatase-1 (PP1; see MIM 176875) is a signal-transducing phosphatase that influences neuronal activity, protein synthesis, metabolism, muscle contraction, and cell division. PPP1R14C is an inhibitor of PP1 (Liu et al., 2002 [PubMed 11812771]).[supplied by OMIM].
Daskalow, K., et al. Anticancer Res. 30(5):1573-1578(2010)
Scholz, S.W., et al. Ann. Neurol. 65(5):610-614(2009)
Burgner, D., et al. PLoS Genet. 5 (1), E1000319 (2009) :
Mungall, A.J., et al. Nature 425(6960):805-811(2003)
Liu, Q.R., et al. J. Biol. Chem. 277(15):13312-13320(2002)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.