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OCA2 Antibody (N-Term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q04671 |
| Other Accession | NP_000266.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 92850 Da |
| Antigen Region | 111-138 aa |
| Gene ID | 4948 |
|---|---|
| Other Names | P protein, Melanocyte-specific transporter protein, Pink-eyed dilution protein homolog, OCA2, D15S12, P |
| Target/Specificity | This OCA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 111-138 amino acids from the N-terminal region of human OCA2. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | OCA2 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | OCA2 (HGNC:8101) |
|---|---|
| Synonyms | D15S12, P |
| Function | Contributes to a melanosome-specific anion (chloride) current that modulates melanosomal pH for optimal tyrosinase activity required for melanogenesis and the melanosome maturation (PubMed:25513726, PubMed:11310796, PubMed:15262401, PubMed:22234890). One of the components of the mammalian pigmentary system (PubMed:15262401, PubMed:18252222, PubMed:7601462). May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color (PubMed:15262401, PubMed:18252222, PubMed:7601462). Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis (By similarity). |
| Cellular Location | Melanosome membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in melanocytes and retinal pigment epithelium. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes the human homologue of the mouse p (pink-eyed dilution) gene. The encoded protein is believed to be an integral membrane protein involved in small molecule transport, specifically tyrosine - a precursor of melanin. Mutations in this gene result in type 2 oculocutaneous albinism. [provided by RefSeq].
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Mengel-From, J., et al. Forensic Sci Int Genet 4(5):323-328(2010)
Ibarrola-Villava, M., et al. Exp. Dermatol. 19(9):836-844(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Eriksson, N., et al. PLoS Genet. 6 (6), E1000993 (2010) :
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