OCA2 Antibody (N-Term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q04671 |
Other Accession | NP_000266.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 92850 Da |
Antigen Region | 111-138 aa |
Gene ID | 4948 |
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Other Names | P protein, Melanocyte-specific transporter protein, Pink-eyed dilution protein homolog, OCA2, D15S12, P |
Target/Specificity | This OCA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 111-138 amino acids from the N-terminal region of human OCA2. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | OCA2 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | OCA2 (HGNC:8101) |
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Synonyms | D15S12, P |
Function | Contributes to a melanosome-specific anion (chloride) current that modulates melanosomal pH for optimal tyrosinase activity required for melanogenesis and the melanosome maturation (PubMed:25513726, PubMed:11310796, PubMed:15262401, PubMed:22234890). One of the components of the mammalian pigmentary system (PubMed:15262401, PubMed:18252222, PubMed:7601462). May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color (PubMed:15262401, PubMed:18252222, PubMed:7601462). Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis (By similarity). |
Cellular Location | Melanosome membrane; Multi-pass membrane protein |
Tissue Location | Expressed in melanocytes and retinal pigment epithelium. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes the human homologue of the mouse p (pink-eyed dilution) gene. The encoded protein is believed to be an integral membrane protein involved in small molecule transport, specifically tyrosine - a precursor of melanin. Mutations in this gene result in type 2 oculocutaneous albinism. [provided by RefSeq].
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Mengel-From, J., et al. Forensic Sci Int Genet 4(5):323-328(2010)
Ibarrola-Villava, M., et al. Exp. Dermatol. 19(9):836-844(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Eriksson, N., et al. PLoS Genet. 6 (6), E1000993 (2010) :
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