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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   FBXO2 Antibody (C-term)   

FBXO2 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • FC - FBXO2 Antibody (C-term) AP10212b
    FBXO2 Antibody (C-term) (Cat. #AP10212b) flow cytometric analysis of HepG2 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
  • WB - FBXO2 Antibody (C-term) AP10212b
    FBXO2 Antibody (C-term) (Cat. #AP10212b) western blot analysis in mouse brain tissue and HepG2,293 cell line lysates (35ug/lane).This demonstrates the FBXO2 antibody detected the FBXO2 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UK22
Other Accession Q80UW2, NP_036300.2
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Antigen Region 244-271 aa
Additional Information
Other Names F-box only protein 2, FBXO2, FBX2
Target/Specificity This FBXO2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 244-271 amino acids from the C-terminal region of human FBXO2.
Dilution FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFBXO2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FBXO2
Synonyms FBX2
Function Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type (By similarity).
Cellular Location Cytoplasm. Microsome membrane; Peripheral membrane protein; Cytoplasmic side EMBL; AF187318; AAF01822.1; -; mRNA EMBL; CR542110; CAG46907.1; -; mRNA EMBL; AK313019; BAG35854.1; -; mRNA EMBL; AL031731; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; CH471130; EAW71689.1; -; Genomic_DNA EMBL; BC025233; AAH25233.1; -; mRNA EMBL; BC096747; AAH96747.1; -; mRNA EMBL; AF174594; AAF04515.1; -; mRNA CCDS; CCDS130.1; - RefSeq; NP_036300.2; NM_012168.5 UniGene; Hs.132753; - UniGene; Hs.556006; - ProteinModelPortal; Q9UK22; - SMR; Q9UK22; - BioGrid; 117623; 54 IntAct; Q9UK22; 8 STRING; 9606.ENSP00000346240; - iPTMnet; Q9UK22; - PhosphoSitePlus; Q9UK22; - BioMuta; FBXO2; - DMDM; 51338836; - EPD; Q9UK22; - jPOST; Q9UK22; - MaxQB; Q9UK22; - PaxDb; Q9UK22; - PeptideAtlas; Q9UK22; - PRIDE; Q9UK22; - ProteomicsDB; 84707; - DNASU; 26232; - Ensembl; ENST00000354287; ENSP00000346240; ENSG00000116661 GeneID; 26232; - KEGG; hsa:26232; - UCSC; uc001asj.4; human CTD; 26232; - DisGeNET; 26232; - EuPathDB; HostDB:ENSG00000116661.9; - GeneCards; FBXO2; - HGNC; HGNC:13581; FBXO2 HPA; HPA005472; - MIM; 607112; gene neXtProt; NX_Q9UK22; - OpenTargets; ENSG00000116661; - PharmGKB; PA31895; - eggNOG; ENOG410IK6V; Eukaryota eggNOG; ENOG4111MF5; LUCA GeneTree; ENSGT00940000160929; - HOGENOM; HOG000231084; - HOVERGEN; HBG003593; - InParanoid; Q9UK22; - KO; K10099; - OMA; IHDESVK; - OrthoDB; 922544at2759; - PhylomeDB; Q9UK22; - TreeFam; TF320527; - Reactome; R-HSA-8951664; Neddylation Reactome; R-HSA-983168; Antigen processing: Ubiquitination & Proteasome degradation UniPathway; UPA00143; - ChiTaRS; FBXO2; human GeneWiki; FBXO2; - GenomeRNAi; 26232; - PRO; PR:Q9UK22; - Proteomes; UP000005640; Chromosome 1 Bgee; ENSG00000116661; Expressed in 187 organ(s), highest expression level in amygdala ExpressionAtlas; Q9UK22; baseline and differential Genevisible; Q9UK22; HS GO; GO:0005737; C:cytoplasm; IDA:ParkinsonsUK-UCL GO; GO:0005829; C:cytosol; ISS:UniProtKB GO; GO:0043197; C:dendritic spine; IEA:Ensembl GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW GO; GO:0031090; C:organelle membrane; IEA:UniProtKB-SubCell GO; GO:0019005; C:SCF ubiquitin ligase complex; ISS:UniProtKB GO; GO:0001540; F:amyloid-beta binding; IEA:Ensembl GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW GO; GO:0004842; F:ubiquitin-protein transferase activity; EXP:Reactome GO; GO:0006464; P:cellular protein modification process; TAS:ProtInc GO; GO:0006516; P:glycoprotein catabolic process; ISS:UniProtKB GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl GO; GO:0043687; P:post-translational protein modification; TAS:Reactome GO; GO:0000209; P:protein polyubiquitination; TAS:Reactome GO; GO:0016567; P:protein ubiquitination; ISS:UniProtKB GO; GO:0006508; P:proteolysis; TAS:ProtInc GO; GO:0031396; P:regulation of protein ubiquitination; IEA:Ensembl GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IEA:Ensembl Gene3D;; -; 1 InterPro; IPR007397; F-box-assoc_dom InterPro; IPR036047; F-box-like_dom_sf InterPro; IPR001810; F-box_dom InterPro; IPR039752; F-box_only InterPro; IPR008979; Galactose-bd-like_sf PANTHER; PTHR12125; PTHR12125; 1 Pfam; PF00646; F-box; 1 Pfam; PF04300; FBA; 1 SMART; SM01198; FBA; 1 SUPFAM; SSF49785; SSF49785; 1 SUPFAM; SSF81383; SSF81383; 1 PROSITE; PS51114; FBA; 1 PROSITE; PS50181; FBOX; 1 1: Evidence at protein level; Complete proteome; Cytoplasm; Endoplasmic reticulum; Lectin; Membrane; Microsome; Polymorphism; Reference proteome; Ubl conjugation pathway CHAIN 1 296 F-box only protein 2 /FTId=PRO_0000119875 DOMAIN 44 91 F-box. {ECO:0000255|PROSITE- ProRule:PRU00080} DOMAIN 113 296 FBA. {ECO:0000255|PROSITE- ProRule:PRU00482} REGION 210 212 Carbohydrate binding. REGION 278 279 Carbohydrate binding. SITE 173 173 Important for carbohydrate binding VARIANT 118 118 K -> T (in dbSNP:rs9614) {ECO:0000269|Ref.2} /FTId=VAR_049036 CONFLICT 45 45 Missing (in Ref. 1; AAF01822) CONFLICT 125 125 R -> C (in Ref. 2; CAG46907) CONFLICT 163 163 E -> D (in Ref. 2; CAG46907) CONFLICT 275 275 D -> G (in Ref. 7; AAF04515) SEQUENCE 296 AA; 33328 MW; 5226F19E27D884AF CRC64; MDGDGDPESV GQPEEASPEE QPEEASAEEE RPEDQQEEEA AAAAAYLDEL PEPLLLRVLA ALPAAELVQA CRLVCLRWKE LVDGAPLWLL KCQQEGLVPE GGVEEERDHW QQFYFLSKRR RNLLRNPCGE EDLEGWCDVE HGGDGWRVEE LPGDSGVEFT HDESVKKYFA SSFEWCRKAQ VIDLQAEGYW EELLDTTQPA IVVKDWYSGR SDAGCLYELT VKLLSEHENV LAEFSSGQVA VPQDSDGGGW MEISHTFTDY GPGVRFVRFE HGGQDSVYWK GWFGARVTNS SVWVEP
Research Areas
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This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is highly similar to the rat NFB42 (neural F Box 42 kDa) protein which is enriched in the nervous system and may play a role in maintaining neurons in a postmitotic state.


Eom, C.Y., et al. Proc. Natl. Acad. Sci. U.S.A. 100(17):9803-9807(2003) Ilyin, G.P., et al. Gene 296 (1-2), 11-20 (2002) : Yoshida, Y., et al. Nature 418(6896):438-442(2002) Winston, J.T., et al. Curr. Biol. 9(20):1180-1182(1999) Cenciarelli, C., et al. Curr. Biol. 9(20):1177-1179(1999)

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$ 325.00
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Cat# AP10212b
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