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L2HGDH Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9H9P8 |
| Other Accession | NP_079160.1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 50316 Da |
| Antigen Region | 132-159 aa |
| Gene ID | 79944 |
|---|---|
| Other Names | L-2-hydroxyglutarate dehydrogenase, mitochondrial, Duranin, L2HGDH, C14orf160 |
| Target/Specificity | This L2HGDH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 132-159 amino acids from the Central region of human L2HGDH. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | L2HGDH Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | L2HGDH |
|---|---|
| Synonyms | C14orf160 |
| Cellular Location | Mitochondrion. |
| Tissue Location | Widely expressed. Highly expressed in brain, testis and muscle. Expressed to a lower extent in lymphocytes, fibroblasts, keratinocytes, placenta, bladder, small intestine, liver and bone marrow. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes L-2-hydroxyglutarate dehydrogenase, a FAD-dependent enzyme that oxidizes L-2-hydroxyglutarate to alpha-ketoglutarate in a variety of mammalian tissues. Mutations in this gene cause L-2-hydroxyglutaric aciduria, a rare autosomal recessive neurometabolic disorder resulting in moderate to severe mental retardation.
References
Short, A.D., et al. Vet. Rec. 167(12):455-457(2010)
Steenweg, M.E., et al. Hum. Mutat. 31(4):380-390(2010)
Kranendijk, M., et al. Hum. Mutat. 31(3):279-283(2010)
Vilarinho, L., et al. J. Hum. Genet. 55(1):55-58(2010)
Haliloglu, G., et al. Neuropediatrics 39(2):119-122(2008)
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