Register or Login
  • All
  • Uniprot Id
  • Catalog #
  • Peptide Sequence
>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   FBXW12 Antibody (C-term)   

FBXW12 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - FBXW12 Antibody (C-term) AP10268b
    FBXW12 Antibody (C-term) (Cat. #AP10268b) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the FBXW12 antibody detected the FBXW12 protein (arrow).
  • IHC-P - FBXW12 Antibody (C-term) AP10268b
    FBXW12 antibody(C-term) (Cat. #AP10268b) immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the FBXW12 antibody(C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - FBXW12 Antibody (C-term) AP10268b
    FBXW12 Antibody (C-term) (Cat. #AP10268b) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q6X9E4
Other Accession NP_001153399.1, NP_001153401.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Antigen Region 291-320 aa
Additional Information
Other Names F-box/WD repeat-containing protein 12, F-box and WD-40 domain-containing protein 12, F-box only protein 35, FBXW12, FBW12, FBXO12, FBXO35
Target/Specificity This FBXW12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 291-320 amino acids from the C-terminal region of human FBXW12.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFBXW12 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FBXW12
Synonyms FBW12, FBXO12, FBXO35
Function Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex.
Tissue Location Ubiquitously expressed. EMBL; AY247969; AAP75562.1; -; mRNA EMBL; AC104448; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; BC101304; AAI01305.1; -; mRNA EMBL; BC101305; AAI01306.1; -; mRNA CCDS; CCDS2764.1; -. [Q6X9E4-1] CCDS; CCDS54577.1; -. [Q6X9E4-3] CCDS; CCDS54578.1; -. [Q6X9E4-2] RefSeq; NP_001153399.1; NM_001159927.1. [Q6X9E4-2] RefSeq; NP_001153401.1; NM_001159929.1. [Q6X9E4-3] RefSeq; NP_996985.2; NM_207102.2. [Q6X9E4-1] RefSeq; XP_016861713.1; XM_017006224.1. [Q6X9E4-1] UniGene; Hs.288793; - ProteinModelPortal; Q6X9E4; - BioGrid; 130052; 9 STRING; 9606.ENSP00000296438; - iPTMnet; Q6X9E4; - PhosphoSitePlus; Q6X9E4; - BioMuta; FBXW12; - DMDM; 215273983; - jPOST; Q6X9E4; - PaxDb; Q6X9E4; - PeptideAtlas; Q6X9E4; - PRIDE; Q6X9E4; - ProteomicsDB; 67792; - ProteomicsDB; 67793; -. [Q6X9E4-2] Ensembl; ENST00000296438; ENSP00000296438; ENSG00000164049. [Q6X9E4-1] Ensembl; ENST00000415155; ENSP00000414683; ENSG00000164049. [Q6X9E4-2] Ensembl; ENST00000445170; ENSP00000406139; ENSG00000164049. [Q6X9E4-3] GeneID; 285231; - KEGG; hsa:285231; - UCSC; uc003csr.3; human. [Q6X9E4-1] CTD; 285231; - EuPathDB; HostDB:ENSG00000164049.14; - GeneCards; FBXW12; - H-InvDB; HIX0019770; - HGNC; HGNC:20729; FBXW12 HPA; HPA037491; - HPA; HPA037492; - MIM; 609075; gene neXtProt; NX_Q6X9E4; - OpenTargets; ENSG00000164049; - PharmGKB; PA134980842; - eggNOG; ENOG410IHPA; Eukaryota eggNOG; ENOG4111ZD7; LUCA GeneTree; ENSGT00940000162557; - HOGENOM; HOG000112541; - HOVERGEN; HBG051564; - InParanoid; Q6X9E4; - KO; K10267; - OMA; GTMIWSS; - OrthoDB; 770934at2759; - PhylomeDB; Q6X9E4; - TreeFam; TF332550; - Reactome; R-HSA-8951664; Neddylation Reactome; R-HSA-983168; Antigen processing: Ubiquitination & Proteasome degradation ChiTaRS; FBXW12; human GenomeRNAi; 285231; - PRO; PR:Q6X9E4; - Proteomes; UP000005640; Chromosome 3 Bgee; ENSG00000164049; Expressed in 57 organ(s), highest expression level in body of pancreas ExpressionAtlas; Q6X9E4; baseline and differential GO; GO:0005829; C:cytosol; TAS:Reactome GO; GO:0004842; F:ubiquitin-protein transferase activity; EXP:Reactome GO; GO:0043687; P:post-translational protein modification; TAS:Reactome GO; GO:0000209; P:protein polyubiquitination; TAS:Reactome Gene3D;; -; 1 InterPro; IPR036047; F-box-like_dom_sf InterPro; IPR001810; F-box_dom InterPro; IPR011044; Quino_amine_DH_bsu InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf Pfam; PF12937; F-box-like; 1 SMART; SM00256; FBOX; 1 SUPFAM; SSF50969; SSF50969; 1 SUPFAM; SSF81383; SSF81383; 1 PROSITE; PS50181; FBOX; 1 2: Evidence at transcript level; Alternative splicing; Complete proteome; Polymorphism; Reference proteome; Repeat; Ubl conjugation pathway; WD repeat CHAIN 1 464 F-box/WD repeat-containing protein 12 /FTId=PRO_0000051000 DOMAIN 1 45 F-box. {ECO:0000255|PROSITE- ProRule:PRU00080} REPEAT 89 132 WD 1 REPEAT 136 174 WD 2 REPEAT 178 217 WD 3 REPEAT 222 263 WD 4 REPEAT 270 315 WD 5 REPEAT 320 367 WD 6 REPEAT 370 407 WD 7 REPEAT 416 461 WD 8 VAR_SEQ 1 29 MEIRLPDLALKRIFSFLDLFGLLQVSQVN -> MSPTHQIQ DP (in isoform 3) /FTId=VSP_044601 VAR_SEQ 136 205 Missing (in isoform 2) /FTId=VSP_042911 VARIANT 6 6 P -> L (in dbSNP:rs17080138) /FTId=VAR_057601 VARIANT 166 166 R -> W (in dbSNP:rs6442117) /FTId=VAR_057602 VARIANT 273 273 V -> D (in dbSNP:rs6784322) /FTId=VAR_057603 CONFLICT 278 278 F -> L (in Ref. 3; AAI01306) CONFLICT 317 317 T -> P (in Ref. 1; AAP75562) SEQUENCE 464 AA; 53056 MW; DFF81F0D718CEF7B CRC64; MEIRLPDLAL KRIFSFLDLF GLLQVSQVNK HWNRIADSDY LWRSLSLQRW DCSNFTNQHL GTHTWKQFFL HQRRKELRLA LAQPHNFIYK VTKNIAFETE LAYLSGNRLT VDEQEKSIIC SVSPKQELCA WDVQEGTMIW SSPVQEFHFS NLVTLPQMHL AITMDRKKTI KVWNCQDRDA LAVLPMPQPC YCMEAYLTKD GPFLMVGDAA GDIYTFTLPG LRDVSKVTAF QYGIVLLHCS PDKKWVFACG TYSRTLPQVF LTESLLRPSE GSVPLSTFLP HKLCASACWT PKVKNRITLM SQSSTGKKTE FITFDLTTKK TGGQTVIQAY EIASFQVAAH LKCPIWMGAS DGYMIVFTSG PYLLLFSITG FLLQRFEDHQ AAINNFWVDP CYVLTTSENS VHVYMWEEGG RHPYLRSCCH LENTWHDHTT DSCISSVMCD NASIVLRVRK VSDSSILVMY SLNT
Research Areas
Citations (0)

Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.

Submit your citation using an Abcepta antibody to, and receive a free "I Love Antibodies" mug.


Members of the F-box protein family, such as FBXW12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM].


Jin, J., et al. Genes Dev. 18(21):2573-2580(2004)
Zeng, L., et al. Mol. Biol. Rep. 31(1):51-57(2004)

Abcepta welcomes feedback from its customers.

If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.

If you have any additional inquiries please email technical services at

$ 325.00
$ 109.00
Cat# AP10268b
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
Request Quote Here

Ordering Information

United States
AlbaniaAustraliaAustriaBelgiumBosnia & HerzegovinaBrazilBulgariaCanadaCentral AmericaChinaCroatiaCyprusCzech RepublicDenmarkEstoniaFinlandFranceGermanyGreeceHong KongHungaryIcelandIndiaIndonesiaIrelandIsraelItalyJapanLatviaLithuaniaLuxembourgMacedoniaMalaysiaMaltaNetherlandsNew ZealandNorwayPakistanPolandPortugalRomaniaSerbiaSingaporeSlovakiaSloveniaSouth AfricaSouth KoreaSpainSwedenSwitzerlandTaiwanTurkeyUnited KingdomUnited StatesVietnamWorldwideOthers
Abcepta, Inc.
(888) 735-7227 / (858) 622-0099
(858) 622-0609
USA Headquarters
(888) 735-7227 / (858) 622-0099 or (858) 875-1900

Shipping Information

Domestic orders (in stock items)
Shipped out the same day. Orders placed after 1 PM (PST) will ship out the next business day.
International orders
Contact your local distributors
Terms & Conditions