FBXW12 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IHC-F, IF |
---|---|
Primary Accession | Q6X9E4 |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 53056 Da |
Gene ID | 285231 |
---|---|
Other Names | F-box/WD repeat-containing protein 12, F-box and WD-40 domain-containing protein 12, F-box only protein 35, FBXW12, FBW12, FBXO12, FBXO35 |
Dilution | WB=1:500-2000,Elisa=1:500-1000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:50-200, |
Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
Name | FBXW12 |
---|---|
Synonyms | FBW12, FBXO12, FBXO35 |
Function | Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (PubMed:26171402). Promotes degradation of interleukin-22 receptor subunit IL22RA1 in resting and IL22-stimulated conditions by facilitating its ubiquitination (PubMed:26171402). Functions as a cell growth suppressor (PubMed:26171402). |
Tissue Location | Ubiquitously expressed. |
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