|Application ||WB, IF, E|
|Calculated MW||42414 Da|
|Antigen Region||244-271 aa|
|Other Names||Homeobox protein Hox-A10, Homeobox protein Hox-18, Homeobox protein Hox-1H, PL, HOXA10, HOX1H|
|Target/Specificity||This HOXA10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 244-271 amino acids from the Central region of human HOXA10.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HOXA10 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5'-AA[AT]TTTTATTAC-3'.|
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Provided below are standard protocols that you may find useful for product applications.
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants encoding different isoforms have been described.
Du, H., et al. Biol. Reprod. 83(2):205-211(2010)
Cheng, W., et al. J. Cancer Res. Clin. Oncol. 136(8):1221-1227(2010)
Liatsikos, S.A., et al. Reprod. Biomed. Online 21(1):126-132(2010)
Godbole, G., et al. J. Reprod. Immunol. 85(2):130-139(2010)
Ko, S.Y., et al. Mol. Cell. Endocrinol. 317 (1-2), 112-119 (2010) :
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