|Application ||FC, IHC-P, WB, E|
|Calculated MW||130501 Da|
|Antigen Region||1069-1097 aa|
|Other Names||Potassium channel subfamily T member 2, Sequence like an intermediate conductance potassium channel subunit, Sodium and chloride-activated ATP-sensitive potassium channel Slo21, KCNT2, SLICK|
|Target/Specificity||This KCNT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1069-1097 amino acids from the C-terminal region of human KCNT2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KCNT2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. Activated by high intracellular sodium and chloride levels (PubMed:14684870, PubMed:16687497, PubMed:29069600). Channel activity is inhibited by ATP and by inhalation anesthetics, such as isoflurane (PubMed:16687497) (By similarity). Inhibited upon stimulation of G-protein coupled receptors, such as CHRM1 and GRM1 (PubMed:16687497).|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Santi, C.M., et al. J. Neurosci. 26(19):5059-5068(2006)
Wei, A.D., et al. Pharmacol. Rev. 57(4):463-472(2005)
Bhattacharjee, A., et al. J. Neurosci. 23(37):11681-11691(2003)
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