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WFDC12 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, IHC-P, E |
|---|---|
| Primary Accession | Q8WWY7 |
| Other Accession | NP_543145.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 12050 Da |
| Antigen Region | 66-94 aa |
| Gene ID | 128488 |
|---|---|
| Other Names | WAP four-disulfide core domain protein 12, Putative protease inhibitor WAP12, Whey acidic protein 2, WFDC12, C20orf122, WAP2 |
| Target/Specificity | This WFDC12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-94 amino acids from the C-terminal region of human WFDC12. |
| Dilution | WB~~1:1000 FC~~1:10~50 IHC-P~~1:50~100 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | WFDC12 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | WFDC12 |
|---|---|
| Synonyms | C20orf122, WAP2 |
| Function | Antibacterial protein. Putative acid-stable proteinase inhibitor. |
| Cellular Location | Secreted. |
| Tissue Location | Highly expressed in prostate, skin, lung and esophagus. Weakly expressed in skeletal muscle, epididymis, kidney, trachea, salivary gland, testis and seminal vesicle |
Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster.
References
Clauss, A., et al. Biochem. Biophys. Res. Commun. 333(2):383-389(2005)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
Clauss, A., et al. Biochem. J. 368 (PT 1), 233-242 (2002) :
Lundwall, A., et al. Biochem. Biophys. Res. Commun. 290(1):452-456(2002)
Deloukas, P., et al. Nature 414(6866):865-871(2001)
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