|Application ||FC, WB, IHC-P, E|
|Other Accession||Q5HZY2, Q5PYH3, Q9CQC9, Q9QVY3, Q3T0T7, NP_057187.1, NP_001028675.1|
|Predicted||Bovine, Hamster, Mouse, Pig, Rat|
|Calculated MW||22410 Da|
|Antigen Region||89-116 aa|
|Other Names||GTP-binding protein SAR1b, GTP-binding protein B, GTBPB, SAR1B, SARA2, SARB|
|Target/Specificity||This SAR1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 89-116 amino acids from the Central region of human SAR1B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SAR1B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex.|
|Cellular Location||Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Note=Associated with the endoplasmic reticulum and Golgi stacks, in particular in the juxta-nuclear Golgi region.|
|Tissue Location||Expressed in many tissues including small intestine, liver, muscle and brain|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a small GTPase that acts as a homodimer. The encoded protein is activated by the guanine nucleotide exchange factor PREB and is involved in protein transport from the endoplasmic reticulum to the Golgi. This protein is part of the COPII coat complex. Defects in this gene are a cause of chylomicron retention disease (CMRD), also known as Anderson disease (ANDD). Two transcript variants encoding the same protein have been found for this gene.
Cefalu, A.B., et al. Metab. Clin. Exp. 59(4):463-467(2010)
Silvain, M., et al. Clin. Genet. 74(6):546-552(2008)
Charcosset, M., et al. Mol. Genet. Metab. 93(1):74-84(2008)
Jardim, D.L., et al. J. Biochem. Mol. Biol. 38(3):328-333(2005)
Jones, B., et al. Nat. Genet. 34(1):29-31(2003)
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