|Application ||WB, E|
|Other Accession||Q7SY75, Q5PQN0, Q91X97, Q4R4N4, P62758, P61602, P37235, P84076, Q06AT1, P84075, P84074, Q4PL64, NP_001035715.1, NP_001035720.1|
|Predicted||Bovine, Pig, Rat, Chicken, Monkey, Xenopus|
|Calculated MW||22245 Da|
|Antigen Region||147-174 aa|
|Other Names||Neurocalcin-delta, NCALD|
|Target/Specificity||This NCALD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 147-174 amino acids from the C-terminal region of human NCALD.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NCALD Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions.|
|Tissue Location||Retina, cerebrum, cerebellum, brain stem, spinal cord, testis, ovary and small intestine|
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Provided below are standard protocols that you may find useful for product applications.
NCALD encodes a member of the neuronal calcium sensor (NCS) family of calcium-binding proteins. The protein contains an N-terminal myristoylation signal and four EF-hand calcium binding loops. The protein is cytosolic at resting calcium levels; however, elevated intracellular calcium levels induce a conformational change that exposes the myristoyl group, resulting in protein association with membranes and partial co-localization with the perinuclear trans-golgi network. The protein is thought to be a regulator of G protein-coupled receptor signal transduction. Several alternatively spliced variants of this gene have been determined, all of which encode the same protein; additional variants may exist but their biological validity has not been determined.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Cirulli, E.T., et al. Eur. J. Hum. Genet. 18(7):815-820(2010)
Gill, M.B., et al. J. Biol. Chem. 284(21):14503-14512(2009)
Venkataraman, V., et al. Biochemistry 47(25):6590-6601(2008)
Kamiyama, M., et al. Hum. Genet. 122 (3-4), 397-407 (2007) :
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