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NCALD Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P61601 |
| Other Accession | Q7SY75, Q5PQN0, Q91X97, Q4R4N4, P62758, P61602, P37235, P84076, Q06AT1, P84075, P84074, Q4PL64, NP_001035715.1, NP_001035720.1 |
| Reactivity | Human, Mouse |
| Predicted | Bovine, Pig, Rat, Chicken, Monkey, Xenopus |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 22245 Da |
| Antigen Region | 147-174 aa |
| Gene ID | 83988 |
|---|---|
| Other Names | Neurocalcin-delta, NCALD |
| Target/Specificity | This NCALD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 147-174 amino acids from the C-terminal region of human NCALD. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NCALD Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NCALD |
|---|---|
| Function | May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions. |
| Tissue Location | Retina, cerebrum, cerebellum, brain stem, spinal cord, testis, ovary and small intestine |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
NCALD encodes a member of the neuronal calcium sensor (NCS) family of calcium-binding proteins. The protein contains an N-terminal myristoylation signal and four EF-hand calcium binding loops. The protein is cytosolic at resting calcium levels; however, elevated intracellular calcium levels induce a conformational change that exposes the myristoyl group, resulting in protein association with membranes and partial co-localization with the perinuclear trans-golgi network. The protein is thought to be a regulator of G protein-coupled receptor signal transduction. Several alternatively spliced variants of this gene have been determined, all of which encode the same protein; additional variants may exist but their biological validity has not been determined.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Cirulli, E.T., et al. Eur. J. Hum. Genet. 18(7):815-820(2010)
Gill, M.B., et al. J. Biol. Chem. 284(21):14503-14512(2009)
Venkataraman, V., et al. Biochemistry 47(25):6590-6601(2008)
Kamiyama, M., et al. Hum. Genet. 122 (3-4), 397-407 (2007) :
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