LY6G6C Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
---|---|
Primary Accession | O95867 |
Other Accession | NP_079537.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 13821 Da |
Antigen Region | 62-90 aa |
Gene ID | 80740 |
---|---|
Other Names | Lymphocyte antigen 6 complex locus protein G6c, LY6G6C, C6orf24, G6C, NG24 |
Target/Specificity | This LY6G6C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 62-90 amino acids from the C-terminal region of human LY6G6C. |
Dilution | WB~~1:1000 IHC-P~~1:50~100 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | LY6G6C Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | LY6G6C |
---|---|
Synonyms | C6orf24, G6C, NG24 |
Cellular Location | Cell membrane; Lipid-anchor, GPI-anchor |
Tissue Location | Highly expressed at the leading edges of cells, on filopodia. |
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Provided below are standard protocols that you may find useful for product applications.
Background
LY6G6C belongs to a cluster of leukocyte antigen-6 (LY6) genes located in the major histocompatibility complex (MHC) class III region on chromosome 6. Members of the LY6 superfamily typically contain 70 to 80 amino acids, including 8 to 10 cysteines. Most LY6 proteins are attached to the cell surface by a glycosylphosphatidylinositol (GPI) anchor that is directly involved in signal transduction (Mallya et al., 2002 [PubMed 12079290]).
References
Bailey, S.D., et al. Diabetes Care (2010) In press :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Barcellos, L.F., et al. PLoS Genet. 5 (10), E1000696 (2009) :
Xie, T., et al. Genome Res. 13(12):2621-2636(2003)
Mallya, M., et al. Genomics 80(1):113-123(2002)
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