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MAP1D Antibody (N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - MAP1D Antibody (N-term) AP10853a
    MAP1D Antibody (Cat. #AP10853a) western blot analysis in mouse spleen cell line lysates (35ug/lane).This demonstrates the MAP1D antibody detected the MAP1D protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q6UB28
Other Accession NP_954697.1
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 37088 Da
Antigen Region 306-334 aa
Additional Information
Gene ID 254042
Other Names Methionine aminopeptidase 1D, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03174}, MAP 1D {ECO:0000255|HAMAP-Rule:MF_03174}, MetAP 1D {ECO:0000255|HAMAP-Rule:MF_03174}, 341118 {ECO:0000255|HAMAP-Rule:MF_03174}, Methionyl aminopeptidase type 1D, mitochondrial, Peptidase M 1D {ECO:0000255|HAMAP-Rule:MF_03174}, METAP1D, MAP1D
Target/Specificity This MAP1D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 306-334 amino acids from the N-terminal region of human MAP1D.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMAP1D Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name METAP1D
Synonyms MAP1D
Function Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed (By similarity). May play a role in colon tumorigenesis.
Cellular Location Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03174, ECO:0000269|PubMed:14532271}
Tissue Location Overexpressed in colon cancer cell lines and colon tumors as compared to normal tissues (at protein level)
Research Areas
Citations (0)
citation

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Background

The N-terminal methionine excision pathway is an essential process in which the N-terminal methionine is removed from many proteins, thus facilitating subsequent protein modification. In mitochondria, enzymes that catalyze this reaction are celled methionine aminopeptidases (MetAps, or MAPs; EC 3.4.11.18) (Serero et al., 2003 [PubMed 14532271]).

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Leszczyniecka, M., et al. Oncogene 25(24):3471-3478(2006)
Serero, A., et al. J. Biol. Chem. 278(52):52953-52963(2003)

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$ 365.00
$ 140.00
Cat# AP10853a
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