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FYB Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O15117 |
| Other Accession | NP_955367.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 85387 Da |
| Antigen Region | 646-675 aa |
| Gene ID | 2533 |
|---|---|
| Other Names | FYN-binding protein, Adhesion and degranulation promoting adaptor protein, ADAP, FYB-120/130, p120/p130, FYN-T-binding protein, SLAP-130, SLP-76-associated phosphoprotein, FYB, SLAP130 |
| Target/Specificity | This FYB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 646-675 amino acids from the C-terminal region of human FYB. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | FYB Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FYB1 (HGNC:4036) |
|---|---|
| Synonyms | FYB, SLAP130 |
| Function | Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (By similarity). May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (PubMed:10747096, PubMed:16980616). Modulates the expression of IL2 (By similarity). Involved in platelet activation (By similarity). Prevents the degradation of SKAP1 and SKAP2 (PubMed:15849195). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity). |
| Cellular Location | Cytoplasm. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768}. Cell junction {ECO:0000250|UniProtKB:O35601}. Note=Colocalizes with TMEM47 at cell- cell contacts in podocytes. {ECO:0000250|UniProtKB:O35601} |
| Tissue Location | Expressed in hematopoietic tissues such as myeloid and T-cells, spleen and thymus. Not expressed in B-cells, nor in non- lymphoid tissues |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
FYB acts as an adapter protein of the FYN and LCP2 signaling cascades in T cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Srivastava, R., et al. J. Biol. Chem. 285(15):11100-11105(2010)
Lehmann, R., et al. Proteomics 9(23):5288-5295(2009)
Voss, M., et al. BMC Immunol. 10, 53 (2009) :
Burbach, B.J., et al. J. Immunol. 181(7):4840-4851(2008)
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