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FYB Antibody
Purified Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | O15117 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Calculated MW | 120 KDa |
| Gene ID | 2533 |
|---|---|
| Other Names | ADAP;Adhesion and degranulation promoting adaptor protein;FYB 120/130;Fyb;FYB-120/130; FYB_HUMAN;FYN binding protein;FYN T binding protein;FYN-binding protein;FYN-T-binding protein;p120/p130;PRO0823;SLAP 130;SLAP-130;SLAP130;SLP 76 associated phosphoprotein; SLP-76-associated phosphoprotein;SLP76 associated phosphoprotein. |
| Dilution | WB~~1:500 |
| Format | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Name | FYB1 (HGNC:4036) |
|---|---|
| Synonyms | FYB, SLAP130 |
| Function | Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (By similarity). May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (PubMed:10747096, PubMed:16980616). Modulates the expression of IL2 (By similarity). Involved in platelet activation (By similarity). Prevents the degradation of SKAP1 and SKAP2 (PubMed:15849195). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity). |
| Cellular Location | Cytoplasm. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768}. Cell junction {ECO:0000250|UniProtKB:O35601}. Note=Colocalizes with TMEM47 at cell- cell contacts in podocytes. {ECO:0000250|UniProtKB:O35601} |
| Tissue Location | Expressed in hematopoietic tissues such as myeloid and T-cells, spleen and thymus. Not expressed in B-cells, nor in non- lymphoid tissues |
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Provided below are standard protocols that you may find useful for product applications.
Background
Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2. May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton.
References
da Silva A.J.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:7493-7498(1997).
Musci M.A.,et al.J. Biol. Chem. 272:11674-11677(1997).
Krause M.,et al.J. Cell Biol. 149:181-194(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Schmutz J.,et al.Nature 431:268-274(2004).
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