ELAC1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q9H777 |
Other Accession | Q29RY4, NP_061166.1 |
Reactivity | Human |
Predicted | Bovine |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 40019 Da |
Antigen Region | 73-101 aa |
Gene ID | 55520 |
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Other Names | Zinc phosphodiesterase ELAC protein 1, Deleted in Ma29, ElaC homolog protein 1, Ribonuclease Z 1, RNase Z 1, tRNA 3 endonuclease 1, tRNase Z 1, ELAC1, D29 |
Target/Specificity | This ELAC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 73-101 amino acids from the N-terminal region of human ELAC1. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | ELAC1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ELAC1 {ECO:0000303|PubMed:32075755, ECO:0000312|HGNC:HGNC:14197} |
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Function | Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity (PubMed:12711671, PubMed:32075755). Specifically involved in tRNA repair: acts downstream of the ribosome- associated quality control (RQC) pathway by removing a 2',3'-cyclic phosphate from tRNAs following cleavage by ANKZF1 (PubMed:32075755). tRNAs are then processed by TRNT1 (PubMed:32075755). |
Cellular Location | Cytoplasm, cytosol. Nucleus. Note=Mainly cytosolic |
Tissue Location | Widely expressed (PubMed:11401430). Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas (PubMed:11401430). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
References
Takahashi, M., et al. FEBS Lett. 582(17):2532-2536(2008)
Takaku, H., et al. Nucleic Acids Res. 31(9):2272-2278(2003)
Yanaihara, N., et al. Genomics 72(2):169-179(2001)
Tavtigian, S.V., et al. Nat. Genet. 27(2):172-180(2001)
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