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ELAC1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9H777 |
| Other Accession | Q29RY4, NP_061166.1 |
| Reactivity | Human |
| Predicted | Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 40019 Da |
| Antigen Region | 73-101 aa |
| Gene ID | 55520 |
|---|---|
| Other Names | Zinc phosphodiesterase ELAC protein 1, Deleted in Ma29, ElaC homolog protein 1, Ribonuclease Z 1, RNase Z 1, tRNA 3 endonuclease 1, tRNase Z 1, ELAC1, D29 |
| Target/Specificity | This ELAC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 73-101 amino acids from the N-terminal region of human ELAC1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ELAC1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ELAC1 {ECO:0000303|PubMed:32075755, ECO:0000312|HGNC:HGNC:14197} |
|---|---|
| Function | Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity (PubMed:12711671, PubMed:32075755). Specifically involved in tRNA repair: acts downstream of the ribosome- associated quality control (RQC) pathway by removing a 2',3'-cyclic phosphate from tRNAs following cleavage by ANKZF1 (PubMed:32075755). tRNAs are then processed by TRNT1 (PubMed:32075755). |
| Cellular Location | Cytoplasm, cytosol. Nucleus. Note=Mainly cytosolic |
| Tissue Location | Widely expressed (PubMed:11401430). Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas (PubMed:11401430). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
References
Takahashi, M., et al. FEBS Lett. 582(17):2532-2536(2008)
Takaku, H., et al. Nucleic Acids Res. 31(9):2272-2278(2003)
Yanaihara, N., et al. Genomics 72(2):169-179(2001)
Tavtigian, S.V., et al. Nat. Genet. 27(2):172-180(2001)
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