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RBMY1A1 Antibody(C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P0DJD3 |
| Other Accession | Q15415, A6NEQ0, P0C7P1, P0DJD4, A6NDE4, Q15414, NP_005049.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 55784 Da |
| Antigen Region | 468-496 aa |
| Gene ID | 5940 |
|---|---|
| Other Names | RNA-binding motif protein, Y chromosome, family 1 member A1, RNA-binding motif protein 1, RNA-binding motif protein 2, Y chromosome RNA recognition motif 1, hRBMY, RBMY1A1, RBM1, RBM2, YRRM1, YRRM2 |
| Target/Specificity | This RBMY1A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 468-496 amino acids from the C-terminal region of human RBMY1A1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RBMY1A1 Antibody(C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RBMY1A1 |
|---|---|
| Synonyms | RBM1, RBM2, YRRM1, YRRM2 |
| Function | RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs. |
| Cellular Location | Nucleus. |
| Tissue Location | Testis-specific.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the C-terminus. Multiple copies of this gene are found in the AZFb azoospermia factor region of chromosome Y and the encoded protein is thought to be involved in spermatogenesis. Most copies of this locus are pseudogenes, although six highly similar copies have full-length ORFs and are considered functional. Four functional copies of this gene are found within inverted repeat IR2; two functional copies of this gene are found in palindrome P3, along with two copies of PTPN13-like, Y-linked. [provided by RefSeq].
References
Dreumont, N., et al. J. Cell. Sci. 123 (PT 1), 40-50 (2010) :
Liu, Y., et al. PLoS Genet. 5 (11), E1000707 (2009) :
Lardone, M.C., et al. Mol. Hum. Reprod. 13(10):705-712(2007)
Skrisovska, L., et al. EMBO Rep. 8(4):372-379(2007)
Lavery, R., et al. Arch. Androl. 53(2):71-73(2007)
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