|Application ||IHC-P, WB, E|
|Calculated MW||15179 Da|
|Antigen Region||103-133 aa|
|Other Names||U6 snRNA-associated Sm-like protein LSm1, Cancer-associated Sm-like, Small nuclear ribonuclear CaSm, LSM1, CASM|
|Target/Specificity||This LSM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 103-133 amino acids from the C-terminal region of human LSM1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LSM1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated (PubMed:18172165). Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation (By similarity).|
|Cellular Location||Cytoplasm. Cytoplasm, P-body|
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Provided below are standard protocols that you may find useful for product applications.
Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family. Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.
Schweinfest C.W., Graber M.W., Chapman J.M., Papas T.S., Baron P.L.,Cancer Res. 57:2961-2965(1997)
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