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LSM1 Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | O15116 |
| Other Accession | Q8VC85 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 15179 Da |
| Antigen Region | 103-133 aa |
| Gene ID | 27257 |
|---|---|
| Other Names | U6 snRNA-associated Sm-like protein LSm1, Cancer-associated Sm-like, Small nuclear ribonuclear CaSm, LSM1, CASM |
| Target/Specificity | This LSM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 103-133 amino acids from the C-terminal region of human LSM1. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | LSM1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LSM1 |
|---|---|
| Synonyms | CASM |
| Function | Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated (PubMed:18172165). Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation (By similarity). |
| Cellular Location | Cytoplasm. Cytoplasm, P-body |
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Provided below are standard protocols that you may find useful for product applications.
Background
Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family. Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.
References
Schweinfest C.W., Graber M.W., Chapman J.M., Papas T.S., Baron P.L.,Cancer Res. 57:2961-2965(1997)
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