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MPZ Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, FC, E |
|---|---|
| Primary Accession | P25189 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 27555 Da |
| Antigen Region | 186-215 aa |
| Gene ID | 4359 |
|---|---|
| Other Names | Myelin protein P0, Myelin peripheral protein, MPP, Myelin protein zero, MPZ |
| Target/Specificity | This MPZ antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 186-215 amino acids from the C-terminal region of human MPZ. |
| Dilution | WB~~1:2000 IHC-P~~1:50~100 FC~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MPZ Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MPZ |
|---|---|
| Function | Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction. |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
| Tissue Location | Found only in peripheral nervous system Schwann cells |
Provided below are standard protocols that you may find useful for product applications.
Background
MPZ is a major structural protein of peripheral myelin. Creation of an extracellular membrane face which guides the wrapping process and ultimately compacts adjacent lamellae.
References
Tachi,N., et.al., Brain Dev. 6 (6), 560-565 (1984)
Hayasaka,K.,et.al., Biochem. Biophys. Res. Commun. 180 (2), 515-518 (1991)
Hayasaka,K., et.al., Genomics 17 (3), 755-758 (1993)
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