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PNOC Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q13519 |
| Other Accession | Q62923, Q64387, O62647 |
| Reactivity | Human |
| Predicted | Bovine, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 20295 Da |
| Antigen Region | 126-151 aa |
| Gene ID | 5368 |
|---|---|
| Other Names | Prepronociceptin, Neuropeptide 1, Nociceptin, Orphanin FQ, PPNOC, Neuropeptide 2, PNOC, OFQ |
| Target/Specificity | This PNOC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 126-151 amino acids from the Central region of human PNOC. |
| Dilution | WB~~1:4000 IHC-P~~1:50~100 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PNOC Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PNOC |
|---|---|
| Synonyms | OFQ |
| Function | [Nociceptin]: Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development. |
| Cellular Location | Secreted. |
| Tissue Location | Predominantly expressed in the brain and spinal cord. Also expressed and secreted by peripheral blood neutrophils following degranulation. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
PNOC is the ligand of the opioid receptor-like receptor (OPRL1). It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. This protein may be involved in neuronal differentiation and development
References
Kuzmin,A., et.al., Brain Res. 1305 SUPPL, S80-S85 (2009)
Rocha,L., et.al., Neurobiol. Dis. 35 (3), 466-473 (2009)
de Krom,M., et.al., Biol. Psychiatry 65 (7), 625-630 (2009)
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