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PNOC Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q13519 |
| Other Accession | Q62923, Q64387, O62647 |
| Reactivity | Human |
| Predicted | Bovine, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 20295 Da |
| Antigen Region | 126-151 aa |
| Gene ID | 5368 |
|---|---|
| Other Names | Prepronociceptin, Neuropeptide 1, Nociceptin, Orphanin FQ, PPNOC, Neuropeptide 2, PNOC, OFQ |
| Target/Specificity | This PNOC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 126-151 amino acids from the Central region of human PNOC. |
| Dilution | IHC-P~~1:50~100 WB~~1:4000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PNOC Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PNOC |
|---|---|
| Synonyms | OFQ |
| Function | [Nociceptin]: Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development. |
| Cellular Location | Secreted. |
| Tissue Location | Predominantly expressed in the brain and spinal cord. Also expressed and secreted by peripheral blood neutrophils following degranulation. |
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Provided below are standard protocols that you may find useful for product applications.
Background
PNOC is the ligand of the opioid receptor-like receptor (OPRL1). It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. This protein may be involved in neuronal differentiation and development
References
Kuzmin,A., et.al., Brain Res. 1305 SUPPL, S80-S85 (2009)
Rocha,L., et.al., Neurobiol. Dis. 35 (3), 466-473 (2009)
de Krom,M., et.al., Biol. Psychiatry 65 (7), 625-630 (2009)
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