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BCL2L12 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant BCL2L12.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF |
|---|---|
| Primary Accession | Q9HB09 |
| Other Accession | BC007724 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 1B1 |
| Calculated MW | 36821 Da |
| Gene ID | 83596 |
|---|---|
| Other Names | Bcl-2-like protein 12, Bcl2-L-12, Bcl-2-related proline-rich protein, BCL2L12, BPR |
| Target/Specificity | BCL2L12 (AAH07724, 174 a.a. ~ 273 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | BCL2L12 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a Bcl-2 homology domain 2 (BH2). The function of this gene has not yet been determined. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
References
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Talmud PJ, et al. Am J Hum Genet, 2009 Nov. PMID 19913121.Molecular analysis and prognostic impact of the novel apoptotic gene BCL2L12 in gastric cancer. Florou D, et al. Biochem Biophys Res Commun, 2010 Jan 1. PMID 19903463.BCL2L12A localizes to the cell nucleus and induces growth inhibition through G2/M arrest in CHO cells. Hong Y, et al. Mol Cell Biochem, 2010 Jan. PMID 19763795.Molecular response of HL-60 cells to mitotic inhibitors vincristine and taxol visualized with apoptosis-related gene expressions, including the new member BCL2L12. Thomadaki H, et al. Ann N Y Acad Sci, 2009 Aug. PMID 19723066.
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