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CPSF6 Antibody (monoclonal) (M10)
Mouse monoclonal antibody raised against a partial recombinant CPSF6.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF |
|---|---|
| Primary Accession | Q16630 |
| Other Accession | NM_007007 |
| Reactivity | Human, Mouse |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 3F11 |
| Calculated MW | 59210 Da |
| Gene ID | 11052 |
|---|---|
| Other Names | Cleavage and polyadenylation specificity factor subunit 6, Cleavage and polyadenylation specificity factor 68 kDa subunit, CFIm68, CPSF 68 kDa subunit, Pre-mRNA cleavage factor Im 68 kDa subunit, Protein HPBRII-4/7, CPSF6, CFIM68 |
| Target/Specificity | CPSF6 (NP_008938, 37 a.a. ~ 136 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | CPSF6 Antibody (monoclonal) (M10) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins.
References
1.Evidence that cleavage factor Im is a heterotetrameric protein complex controlling alternative polyadenylation.Kim S, Yamamoto J, Chen Y, Aida M, Wada T, Handa H, Yamaguchi Y.Genes Cells. 2010 Sep 1;15(9):1003-13. Epub 2010 Jul 29.2.Novel snail1 target proteins in human colon cancer identified by proteomic analysis.Larriba MJ, Casado-Vela J, Pendas-Franco N, Pena R, Garcia de Herreros A, Berciano MT, Lafarga M, Casal JI, Munoz A.PLoS One. 2010 Apr 20;5(4):e10221.
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