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CYGB Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant CYGB.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IF |
|---|---|
| Primary Accession | Q8WWM9 |
| Other Accession | BC029798 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a kappa |
| Clone Names | 3A5-2D2 |
| Calculated MW | 21405 Da |
| Gene ID | 114757 |
|---|---|
| Other Names | Cytoglobin, Histoglobin, HGb, Stellate cell activation-associated protein, CYGB, STAP |
| Target/Specificity | CYGB (AAH29798, 1 a.a. ~ 190 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | CYGB Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Cytoglobin is a ubiquitously expressed hexacoordinate hemoglobin that may facilitate diffusion of oxygen through tissues, scavenge nitric oxide or other reactive oxygen species, or serve a protective function during oxidative stress (Trent and Hargrove, 2002 [PubMed 11893755]).
References
Cytoglobin conformations and disulfide bond formation. Lechauve C, et al. FEBS J, 2010 Jun. PMID 20553503.Nitric-oxide dioxygenase function of human cytoglobin with cellular reductants and in rat hepatocytes. Gardner AM, et al. J Biol Chem, 2010 Jul 30. PMID 20511233.Cytoglobin is upregulated by tumour hypoxia and silenced by promoter hypermethylation in head and neck cancer. Shaw RJ, et al. Br J Cancer, 2009 Jul 7. PMID 19568272.Cytoglobin is expressed in the vasculature and regulates cell respiration and proliferation via nitric oxide dioxygenation. Halligan KE, et al. J Biol Chem, 2009 Mar 27. PMID 19147491.Patterns of distribution of oxygen-binding globins, neuroglobin and cytoglobin in human retina. Ostoji? J, et al. Arch Ophthalmol, 2008 Nov. PMID 19001220.
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