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CYGB Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a full length recombinant CYGB.
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, IF, E |
|---|---|
| Primary Accession | Q8WWM9 |
| Other Accession | BC029798 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 1A1 |
| Calculated MW | 21405 Da |
| Gene ID | 114757 |
|---|---|
| Other Names | Cytoglobin, Histoglobin, HGb, Stellate cell activation-associated protein, CYGB, STAP |
| Target/Specificity | CYGB (AAH29798, 1 a.a. ~ 190 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IHC~~1:100~500 IF~~1:50~200 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | CYGB Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures. |
Provided below are standard protocols that you may find useful for product applications.
Background
Cytoglobin is a ubiquitously expressed hexacoordinate hemoglobin that may facilitate diffusion of oxygen through tissues, scavenge nitric oxide or other reactive oxygen species, or serve a protective function during oxidative stress (Trent and Hargrove, 2002 [PubMed 11893755]).
References
1.Cytoglobin has bimodal: tumour suppressor and oncogene functions in lung cancer cell lines.Oleksiewicz U, Liloglou T, Tasopoulou KM, Daskoulidou N, Bryan J, Gosney JR, Field JK, Xinarianos GHum Mol Genet. 2013 Apr 24.2.Pathway specific gene expression profiling reveals oxidative stress genes potentially regulated by transcription co-activator LEDGF/p75 in prostate cancer cells.Basu A, Drame A, Munoz R, Gijsbers R, Debyser Z, De Leon M, Casiano CA.Prostate. 2011 Jul 27. doi: 10.1002/pros.21463. [Epub ahead of print]3.p53-mediated apoptosis, neuroglobin overexpression, and globin deposits in a patient with hereditary ferritinopathy.Powers JM.J Neuropathol Exp Neurol. 2006 Jul;65(7):716-21.4.Hypoxia differentially regulates the expression of neuroglobin and cytoglobin in rat brain.Li RC, Lee SK, Pouranfar F, Brittian KR, Clair HB, Row BW, Wang Y, Gozal D.Brain Res. 2006 Jun 22;1096(1):173-9. Epub 2006 Jun 5.
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