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DKK1 Antibody (monoclonal) (M11)
Mouse monoclonal antibody raised against a full length recombinant DKK1.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, IP |
|---|---|
| Primary Accession | O94907 |
| Other Accession | BC001539 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2b Kappa |
| Clone Names | 2A5 |
| Calculated MW | 28672 Da |
| Gene ID | 22943 |
|---|---|
| Other Names | Dickkopf-related protein 1, Dickkopf-1, Dkk-1, hDkk-1, SK, DKK1 |
| Target/Specificity | DKK1 (AAH01539.1, 1 a.a. ~ 266 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | DKK1 Antibody (monoclonal) (M11) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.
References
1.Genetic grouping of medulloblastomas by representative markers in pathologic diagnosis.Min HS, Lee JY, Kim SK, Park SHTransl Oncol. 2013 Jun 1;6(3):265-72. Print 2013 Jun.2.RNA interference?mediated targeting of DKK1 gene expression in Ishikawa endometrial carcinoma cells causes increased tumor cell invasion and migration.Yi N, Liao QP, Li ZH, Xie BJ, Hu YH, Yi W, Liu M.ONCOLOGY LETTERS 6: 756-762, 20133.Molecular subgroups of medulloblastoma: the current consensus.Taylor MD, Northcott PA, Korshunov A, Remke M, Cho YJ, Clifford SC, Eberhart CG, Parsons DW, Rutkowski S, Gajjar A, Ellison DW, Lichter P, Gilbertson RJ, Pomeroy SL, Kool M, Pfister SM.Acta Neuropathol. 2011 Dec 2.4.Prokineticin 1 induces Dickkopf 1 expression and regulates cell proliferation and decidualization in the human endometrium.Macdonald LJ, Sales KJ, Grant V, Brown P, Jabbour HN, Catalano RD.Mol Hum Reprod. 2011 May 5. [Epub ahead of print]5.Carbonic anhydrase IX (CA9) modulates tumor-associated cell migration and invasion.Shin HJ, Rho SB, Jung DC, Han IO, Oh ES, Kim JY.J Cell Sci. 2011 Apr 1;124(Pt 7):1077-87. Epub 2011 Mar 1.6.Bone and bone marrow pro-osteoclastogenic cytokines are up-regulated in osteoporosis fragility fractures.D'Amelio P, Roato I, D'Amico L, Veneziano L, Suman E, Sassi F, Bisignano G, Ferracini R, Gargiulo G, Castoldi F, Pescarmona GP, Isaia GC.Osteoporos Int. 2010 Nov 30. [Epub ahead of print]
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