|Other Names||Visinin-like protein 1, VILIP, VLP-1, Hippocalcin-like protein 3, HLP3, VSNL1, VISL1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner.|
|Tissue Location||Brain and retina. Neuron-specific in the central and peripheral nervous system. Increased in the cerebrospinal fluid of Alzheimer disease patients (at protein level).|
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This gene is a member of the visinin/recoverin subfamilyof neuronal calcium sensor proteins. The encoded protein isstrongly expressed in granule cells of the cerebellum where itassociates with membranes in a calcium-dependent manner andmodulates intracellular signaling pathways of the central nervoussystem by directly or indirectly regulating the activity ofadenylyl cyclase. Alternatively spliced transcript variants havebeen observed, but their full-length nature has not beendetermined.
Xu, Y., et al. Schizophr. Res. 119 (1-3), 219-227 (2010) :Buttgereit, J., et al. Regul. Pept. 161 (1-3), 51-57 (2010) :Fu, J., et al. J. Biol. Chem. 284(40):27577-27586(2009)Chen, K.C., et al. J. Pept. Sci. 15(2):89-94(2009)Zhao, C.J., et al. Mol. Cell. Neurosci. 40(2):280-292(2009)
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