|Application ||FC, IHC-P, WB, E|
|Other Accession||P62762, P62761, Q4R5F7, P62764, P62763, P35332, Q8BGZ1, Q9UM19, P29104, NP_003376|
|Predicted||Bovine, Rat, Chicken, Monkey|
|Calculated MW||22142 Da|
|Antigen Region||47-75 aa|
|Other Names||Visinin-like protein 1, VILIP, VLP-1, Hippocalcin-like protein 3, HLP3, VSNL1, VISL1|
|Target/Specificity||This VSNL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 47-75 amino acids from the Central region of human VSNL1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||VSNL1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner.|
|Tissue Location||Brain and retina. Neuron-specific in the central and peripheral nervous system. Increased in the cerebrospinal fluid of Alzheimer disease patients (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the visinin/recoverin subfamily of neuronal calcium sensor proteins. The encoded protein is strongly expressed in granule cells of the cerebellum where it associates with membranes in a calcium-dependent manner and modulates intracellular signaling pathways of the central nervous system by directly or indirectly regulating the activity of adenylyl cyclase. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined.
Xu, Y., et al. Schizophr. Res. 119 (1-3), 219-227 (2010) :
Buttgereit, J., et al. Regul. Pept. 161 (1-3), 51-57 (2010) :
Fu, J., et al. J. Biol. Chem. 284(40):27577-27586(2009)
Chen, K.C., et al. J. Pept. Sci. 15(2):89-94(2009)
Zhao, C.J., et al. Mol. Cell. Neurosci. 40(2):280-292(2009)
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