|Other Names||Mitotic spindle assembly checkpoint protein MAD1, Mitotic arrest deficient 1-like protein 1, MAD1-like protein 1, Mitotic checkpoint MAD1 protein homolog, HsMAD1, hMAD1, Tax-binding protein 181, MAD1L1, MAD1, TXBP181|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. May recruit MAD2L1 to unattached kinetochores. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding.|
|Cellular Location||Nucleus. Chromosome, centromere, kinetochore. Nucleus envelope. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Detected at the nucleus envelope during interphase (PubMed:22351768). From the beginning to the end of mitosis, it is seen to move from a diffusely nuclear distribution to the centrosome, to the spindle midzone and finally to the midbody. Detected at kinetochores during prometaphase (PubMed:22351768). Colocalizes with NEK2 at the kinetochore (PubMed:14978040). Colocalizes with IK at spindle poles during metaphase and anaphase (PubMed:22351768)|
|Tissue Location||Expressed weakly at G0/G1 and highly at late S and G2/M phase|
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MAD1L1 is a component of the mitotic spindle-assemblycheckpoint that prevents the onset of anaphase until all chromosomeare properly aligned at the metaphase plate. MAD1L1 functions as ahomodimer and interacts with MAD2L1. MAD1L1 may play a role in cellcycle control and tumor suppression. Three transcript variantsencoding the same protein have been found for this gene. [providedby RefSeq].
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Guo, Y., et al. J. Med. Genet. 47(9):616-622(2010)Wang, H.B., et al. J. Gastrointest. Surg. 14(8):1227-1234(2010)Hewitt, L., et al. J. Cell Biol. 190(1):25-34(2010)Ge, Z., et al. FASEB J. 24(2):579-586(2010)
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