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PRPH2 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P23942 |
|---|---|
| Clone Names | 100311175 |
| Gene ID | 5961 |
|---|---|
| Other Names | Peripherin-2, Retinal degeneration slow protein, Tetraspanin-22, Tspan-22, PRPH2, PRPH, RDS, TSPAN22 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PRPH2 |
|---|---|
| Synonyms | PRPH, RDS, TSPAN22 |
| Function | Essential for retina photoreceptor outer segment disk morphogenesis, may also play a role with ROM1 in the maintenance of outer segment disk structure (By similarity). Required for the maintenance of retinal outer nuclear layer thickness (By similarity). Required for the correct development and organization of the photoreceptor inner segment (By similarity). |
| Cellular Location | Membrane {ECO:0000250|UniProtKB:P17810}; Multi- pass membrane protein. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:P15499} Photoreceptor inner segment {ECO:0000250|UniProtKB:P15499} |
| Tissue Location | Retina (photoreceptor). In rim region of ROS (rod outer segment) disks |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of thetransmembrane 4 superfamily, also known as the tetraspanin family.Most of these members are cell-surface proteins that arecharacterized by the presence of four hydrophobic domains. Theproteins mediate signal transduction events that play a role in theregulation of cell development, activation, growth and motility.This encoded protein is a cell surface glycoprotein found in theouter segment of both rod and cone photoreceptor cells. It mayfunction as an adhesion molecule involved in stabilization andcompaction of outer segment disks or in the maintenance of thecurvature of the rim. This protein is essential for diskmorphogenesis. Defects in this gene are associated with bothcentral and peripheral retinal degenerations. Some of the variousphenotypically different disorders are autosomal dominant retinitispigmentosa, progressive macular degeneration, macular dystrophy andretinitis pigmentosa digenic.
References
Poloschek, C.M., et al. Invest. Ophthalmol. Vis. Sci. 51(8):4253-4265(2010)Vos, W.L., et al. Eur. Biophys. J. 39(4):679-688(2010)Matias-Florentino, M., et al. Curr. Eye Res. 34(12):1050-1056(2009)Lim, K.P., et al. Arch. Ophthalmol. 127(6):784-790(2009)Anand, S., et al. Retina (Philadelphia, Pa.) 29(5):682-688(2009)
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