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PRPH2 Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P23942
Clone Names 100311175
Peptide ID 100311175
Additional Information
Gene ID 5961
Other Names Peripherin-2, Retinal degeneration slow protein, Tetraspanin-22, Tspan-22, PRPH2, PRPH, RDS, TSPAN22
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PRPH2
Synonyms PRPH, RDS, TSPAN22
Function May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis.
Cellular Location Membrane; Multi-pass membrane protein.
Tissue Location Retina (photoreceptor). In rim region of ROS (rod outer segment) disks
Research Areas
Citations (0)

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The protein encoded by this gene is a member of thetransmembrane 4 superfamily, also known as the tetraspanin family.Most of these members are cell-surface proteins that arecharacterized by the presence of four hydrophobic domains. Theproteins mediate signal transduction events that play a role in theregulation of cell development, activation, growth and motility.This encoded protein is a cell surface glycoprotein found in theouter segment of both rod and cone photoreceptor cells. It mayfunction as an adhesion molecule involved in stabilization andcompaction of outer segment disks or in the maintenance of thecurvature of the rim. This protein is essential for diskmorphogenesis. Defects in this gene are associated with bothcentral and peripheral retinal degenerations. Some of the variousphenotypically different disorders are autosomal dominant retinitispigmentosa, progressive macular degeneration, macular dystrophy andretinitis pigmentosa digenic.


Poloschek, C.M., et al. Invest. Ophthalmol. Vis. Sci. 51(8):4253-4265(2010)Vos, W.L., et al. Eur. Biophys. J. 39(4):679-688(2010)Matias-Florentino, M., et al. Curr. Eye Res. 34(12):1050-1056(2009)Lim, K.P., et al. Arch. Ophthalmol. 127(6):784-790(2009)Anand, S., et al. Retina (Philadelphia, Pa.) 29(5):682-688(2009)

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Cat# BP12554a
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