|Other Names||Keratocan, KTN, Keratan sulfate proteoglycan keratocan, KERA, SLRR2B|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Cornea (at protein level) (PubMed:10802664, PubMed:11683372). Increased expression in the stroma of keratoconus corneas (PubMed:11683372). Also detected in trachea, and in low levels, in intestine, skeletal muscle, ovary, lung and putamen (PubMed:10802664).|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a keratan sulfateproteoglycan that is involved in corneal transparency. Defects inthis gene are a cause of autosomal recessive cornea plana 2 (CNA2).
Aldave, A.J., et al. Invest. Ophthalmol. Vis. Sci. 51(8):4006-4012(2010)Dimasi, D.P., et al. Mol. Vis. 16, 562-569 (2010) :Wheeler, H.E., et al. PLoS Genet. 5 (10), E1000685 (2009) :Melrose, J., et al. Arthritis Res. Ther. 10 (4), R79 (2008) :Liskova, P., et al. Mol. Vis. 13, 1339-1347 (2007) :
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