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KERA Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O60938 |
|---|---|
| Clone Names | 100318253 |
| Gene ID | 11081 |
|---|---|
| Other Names | Keratocan, KTN, Keratan sulfate proteoglycan keratocan, KERA, SLRR2B |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | KERA |
|---|---|
| Synonyms | SLRR2B |
| Function | May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix. |
| Cellular Location | Secreted, extracellular space, extracellular matrix |
| Tissue Location | Cornea (at protein level) (PubMed:10802664, PubMed:11683372). Increased expression in the stroma of keratoconus corneas (PubMed:11683372). Also detected in trachea, and in low levels, in intestine, skeletal muscle, ovary, lung and putamen (PubMed:10802664). |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a keratan sulfateproteoglycan that is involved in corneal transparency. Defects inthis gene are a cause of autosomal recessive cornea plana 2 (CNA2).
References
Aldave, A.J., et al. Invest. Ophthalmol. Vis. Sci. 51(8):4006-4012(2010)Dimasi, D.P., et al. Mol. Vis. 16, 562-569 (2010) :Wheeler, H.E., et al. PLoS Genet. 5 (10), E1000685 (2009) :Melrose, J., et al. Arthritis Res. Ther. 10 (4), R79 (2008) :Liskova, P., et al. Mol. Vis. 13, 1339-1347 (2007) :
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