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TMEM43 Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q9BTV4
Clone Names 100318261
Peptide ID 100318261
Additional Information
Gene ID 79188
Other Names Transmembrane protein 43, Protein LUMA, TMEM43
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TMEM43
Function May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane (By similarity).
Cellular Location Endoplasmic reticulum. Nucleus inner membrane; Multi-pass membrane protein. Note=Retained in the inner nuclear membrane through interaction with EMD and A- and B- lamins. The N- and C-termini are oriented towards the nucleoplasm The majority of the hydrophilic domain resides in the endoplasmic reticulum lumen (By similarity).
Tissue Location Highest expression in placenta. Also found at lower levels in heart, ovary, spleen, small intestine, thymus, prostate and testis.
Research Areas
Citations (0)

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This gene belongs to the TMEM43 family. Defects in thisgene are the cause of familial arrhythmogenic right ventriculardysplasia type 5 (ARVD5), also known as arrhythmogenic rightventricular cardiomyopathy type 5 (ARVC5). Arrhythmogenic rightventricular dysplasia is an inherited disorder, often involvingboth ventricles, and is characterized by ventricular tachycardia,heart failure, sudden cardiac death, and fibrofatty replacement ofcardiomyocytes. This gene contains a response element for PPARgamma (an adipogenic transcription factor), which may explain thefibrofatty replacement of the myocardium, a characteristicpathological finding in ARVC.


Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Barahona-Dussault, C., et al. Clin. Genet. 77(1):37-48(2010)Hodgkinson, K., et al. Genet. Med. 11(12):859-865(2009)Merner, N.D., et al. Am. J. Hum. Genet. 82(4):809-821(2008)Bengtsson, L., et al. J. Cell. Sci. 121 (PT 4), 536-548 (2008) :

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Cat# BP12618c
Availability: Back Order
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