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DRG1 Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9Y295
Clone Names 100324017
Peptide ID 100324017
Additional Information
Gene ID 4733
Other Names Developmentally-regulated GTP-binding protein 1, DRG-1, Neural precursor cell expressed developmentally down-regulated protein 3, NEDD-3, DRG1, NEDD3
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DRG1 {ECO:0000303|PubMed:29915238, ECO:0000312|HGNC:HGNC:3029}
Function Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP (PubMed:29915238, PubMed:23711155). Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions (PubMed:23711155). When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation (PubMed:19819225, PubMed:29915238). Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions (PubMed:28855639).
Cellular Location Nucleus. Cytoplasm Note=The DRG1-ZC3H15/DFRP1 complex associates with polysomes
Tissue Location High levels in skeletal muscle, heart, and kidney. Intermediate levels in liver, placenta and brain. Low levels in colon, thymus, spleen, small intestine, lung and leukocytes.
Research Areas
Citations (0)

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Background

DRG1 may play a role in cell proliferation, differentiation and death.

References

de Krom, M., et al. Biol. Psychiatry 65(7):625-630(2009)Bandyopadhyay, S., et al. Cancer Res. 66(24):11983-11990(2006)Bandyopadhyay, S., et al. Oncogene 23(33):5675-5681(2004)Collins, J.E., et al. Genome Biol. 5 (10), R84 (2004) :Bandyopadhyay, S., et al. Cancer Res. 63(8):1731-1736(2003)

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Cat# BP12620b
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