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DRG1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, IHC-P, WB, E |
|---|---|
| Primary Accession | Q9Y295 |
| Other Accession | P32233, Q3MHP5, NP_004138.1 |
| Reactivity | Human |
| Predicted | Bovine, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 40542 Da |
| Antigen Region | 334-363 aa |
| Gene ID | 4733 |
|---|---|
| Other Names | Developmentally-regulated GTP-binding protein 1, DRG-1, Neural precursor cell expressed developmentally down-regulated protein 3, NEDD-3, DRG1, NEDD3 |
| Target/Specificity | This DRG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 334-363 amino acids from the C-terminal region of human DRG1. |
| Dilution | WB~~1:2000 IHC-P~~1:10~50 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | DRG1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DRG1 {ECO:0000303|PubMed:29915238, ECO:0000312|HGNC:HGNC:3029} |
|---|---|
| Function | Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP (PubMed:29915238, PubMed:23711155). Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions (PubMed:23711155). When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation (PubMed:19819225, PubMed:29915238). Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions (PubMed:28855639). |
| Cellular Location | Nucleus. Cytoplasm. Note=The DRG1-ZC3H15/DFRP1 complex associates with polysomes |
| Tissue Location | High levels in skeletal muscle, heart, and kidney. Intermediate levels in liver, placenta and brain. Low levels in colon, thymus, spleen, small intestine, lung and leukocytes |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
DRG1 may play a role in cell proliferation, differentiation and death.
References
de Krom, M., et al. Biol. Psychiatry 65(7):625-630(2009)
Bandyopadhyay, S., et al. Cancer Res. 66(24):11983-11990(2006)
Bandyopadhyay, S., et al. Oncogene 23(33):5675-5681(2004)
Collins, J.E., et al. Genome Biol. 5 (10), R84 (2004) :
Bandyopadhyay, S., et al. Cancer Res. 63(8):1731-1736(2003)
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