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XYLT1 Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q86Y38
Clone Names 100318136
Peptide ID 100318136
Additional Information
Gene ID 64131
Other Names Xylosyltransferase 1, Peptide O-xylosyltransferase 1, Xylosyltransferase I, XT-I, XylT-I, XYLT1, XT1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name XYLT1
Synonyms XT1
Function Catalyzes the first step in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans, such as DCN. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein (PubMed:15461586, PubMed:17189265, PubMed:24581741, PubMed:23982343). Required for normal embryonic and postnatal skeleton development, especially of the long bones (PubMed:24581741, PubMed:23982343). Required for normal maturation of chondrocytes during bone development, and normal onset of ossification (By similarity).
Cellular Location Golgi apparatus membrane; Single-pass type II membrane protein. Secreted Note=Detected predominantly in the Golgi apparatus
Tissue Location Widely expressed. Expressed at higher level in placenta, kidney and pancreas. Weakly expressed in skeletal muscle.
Research Areas
Citations (0)

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This locus encodes a xylosyltransferase enzyme. Theencoded protein catalyzes transfer of UDP-xylose to serine residuesof an acceptor protein substrate. This transfer reaction isnecessary for biosynthesis of glycosaminoglycan chains. Mutationsin this gene have been associated with increased severity ofpseudoxanthoma elasticum.


Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Muller, B., et al. J. Biol. Chem. 284(45):30775-30782(2009)Ponighaus, C., et al. Am. J. Hypertens. 22(4):432-436(2009)Ambrosius, M., et al. Clin. Biochem. 42 (1-2), 1-4 (2009) :Schon, S., et al. J. Med. Genet. 43(9):745-749(2006)

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Cat# BP12779a
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