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RFX2 Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P48378
Clone Names 100324254
Peptide ID 100324254
Additional Information
Gene ID 5990
Other Names DNA-binding protein RFX2, Regulatory factor X 2, RFX2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name RFX2
Function Transcription factor that acts as a key regulator of spermatogenesis. Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such as genes required for cilium assembly and function (By similarity). Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters (PubMed:10330134). Probably activates transcription of the testis- specific histone gene HIST1H1T (By similarity).
Cellular Location Nucleus {ECO:0000250|UniProtKB:B2GV50, ECO:0000255|PROSITE-ProRule:PRU00858}. Cytoplasm {ECO:0000250|UniProtKB:B2GV50}. Note=Mainly expressed in the nucleus and at lower level in cytoplasm {ECO:0000250|UniProtKB:B2GV50}
Research Areas
Citations (0)

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This gene is a member of the regulatory factor X genefamily, which encodes transcription factors that contain ahighly-conserved winged helix DNA binding domain. The proteinencoded by this gene is structurally related to regulatory factorsX1, X3, X4, and X5. It is a transcriptional activator that can bindDNA as a monomer or as a heterodimer with other RFX family members.This protein can bind to cis elements in the promoter of the IL-5receptor alpha gene. Two transcript variants encoding differentisoforms have been described for this gene, and both variantsutilize alternative polyadenylation sites.


Purvis, T.L., et al. Gene 460 (1-2), 20-29 (2010) :Bailey, S.D., et al. Diabetes Care (2010) In press :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Horvath, G.C., et al. Biol. Reprod. 71(5):1551-1559(2004)Maijgren, S., et al. Arch. Dermatol. Res. 295(11):482-489(2004)

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Cat# BP12817b
Availability: Back Order
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