Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
FCAR Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P24071 |
|---|---|
| Clone Names | 90713061 |
| Gene ID | 2204 |
|---|---|
| Other Names | Immunoglobulin alpha Fc receptor, IgA Fc receptor, CD89, FCAR, CD89 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | FCAR |
|---|---|
| Synonyms | CD89 |
| Function | Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production. |
| Cellular Location | [Isoform A.1]: Cell membrane; Single-pass type I membrane protein [Isoform A.3]: Cell membrane; Single-pass type I membrane protein [Isoform B-delta-S2]: Secreted. |
| Tissue Location | Isoform A.1, isoform A.2 and isoform A.3 are differentially expressed between blood and mucosal myeloid cells Isoform A.1, isoform A.2 and isoform A.3 are expressed in monocytes Isoform A.1 and isoform A.2 are expressed in alveolar macrophages; however only one isoform is expressed at alveolar macrophages surfaces |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of the immunoglobulin genesuperfamily and encodes a receptor for the Fc region of IgA. Thereceptor is a transmembrane glycoprotein present on the surface ofmyeloid lineage cells such as neutrophils, monocytes, macrophages,and eosinophils, where it mediates immunologic responses topathogens. It interacts with IgA-opsonized targets and triggersseveral immunologic defense processes, including phagocytosis,antibody-dependent cell-mediated cytotoxicity, and stimulation ofthe release of inflammatory mediators. Multiple alternativelyspliced transcript variants encoding different isoforms have beendescribed for this gene.
References
Vuong, M.T., et al. Kidney Int. (2010) In press :Davila, S., et al. Genes Immun. 11(3):232-238(2010)Peng, M., et al. Cell Res. 20(2):223-237(2010)Kobayashi, T., et al. J. Dent. Res. 88(12):1137-1141(2009)van der Steen, L., et al. Gastroenterology 137(6):2018-2029(2009)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Other Products
Shipping Information
