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DCNP1 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8TF63 |
|---|---|
| Clone Names | 91119016 |
| Gene ID | 140947 |
|---|---|
| Other Names | Dendritic cell nuclear protein 1, Dendritic cell nuclear protein-1, Dendritic cell-associated nuclear protein, DCANP1 (HGNC:24459) |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | DCANP1 (HGNC:24459) |
|---|---|
| Function | Binds with and transactivates the corticotropin-releasing hormone (CRH) promoter. |
| Cellular Location | Nucleus. Cytoplasm Note=Particularly on the periphery. Colocalizes with corticotropin- releasing hormone (CRH) in parvocellular neurons in the paraventricular nucleus. |
| Tissue Location | Expressed in neurons of the paraventricular nucleus, thalamus and occipital cortex and in glial cells (at protein level). Predominantly expressed in dendritic cells. Detected in brain and skeletal muscle. Highly expressed in mature dendritic cells and at a lower level in immature dendritic cells. Expressed in paraventricular nucleus, supraoptic nucleus and nucleus basalis of Meynert. Strongly expressed in paraventricular nucleus of depressed patients compared to controls. Not expressed in monocytes and B-cells |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This intronless gene is specifically expressed indendritic cells (DCs), which are potent antigen-presenting cellsinvolved in activating naive T cells to initiate antigen-specificimmune response. The encoded protein is localized mainly in theperinucleus. One of the alleles (A/T) of this gene, that causespremature translation termination at aa 117, has been associatedwith an increased prevalence of major depression in humans.
References
Zhou, T., et al. Brain 133(10):3069-3079(2010)Bosker, F.J., et al. Mol. Psychiatry (2010) In press :Kim, Y., et al. Genes Immun. 8(5):369-378(2007)Lamesch, P., et al. Genomics 89(3):307-315(2007)Willis-Owen, S.A., et al. Mol. Psychiatry 11(2):121-122(2006)
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